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Recently, an increasing number of studies have shown that lncRNAs can involve in various critical biological processes and a number of complex human diseases. Log-likelihood ratio of coding versus noncoding based on empirical frequencies of all codon substitutions in combination with evolutionary information for several organisms. In the fourth step, strategies are employed to functionally annotate the lncRNAs. Algorithms are developed to infer the candidate functions of the lncRNAs in the network model. Long noncoding RNA as modular scaffold of histone modification complexes.

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    Vielen Dank an das DateTeam. Accumulating associations between lncRNAs and other molecules are also predicted by computational methods or verified by experimental means [ 6389 ].

    Liebes Team, ihr habt hier eine super Seite, vielen Dank. Nucleic Acids Res ; 41 2: Analysis of the expression profiles of lncRNAs in a variety of cancer cells, and their comparison with that in corresponding normal cells, demonstrated that many lncRNAs are dysregulated in a wide range of cancers [ 18 ].

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    Evolution and functions of long noncoding RNAs.

    Dann kam der entscheidende Smiley! Nucleic Acids Res ; 42 D1: After obtaining the input data, in the second step, the mixture expression profiles for lncRNAs and mRNAs or other molecules are constructed. Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts.

    We believe that this review will enable researchers to understand the key issues, and facilitate further advances in understanding the lncRNAs.

    Here, we review recent, state-of-the-art advances in the three levels the primary sequence, the secondary structure and the function annotation of the lncRNA research, as well as computational methods for lncRNA data analysis.

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    Nucleic Acids Res ; 42 D1: Partnersuche ab 50 in der Schweiz.

    And the roster of biological events in which lncRNAs are key factors is rapidly growing. The authors thank Junyan Zhang, Jinglong Zheng in our lab for tedious material collecting for the writing of the manuscript.

    The co-expression network between lncRNAs and other molecules can also be constructed based on the co-expression analysis.

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    Nat Protoc ; 8 5: High-throughput sequencing-based methods may shed light on probing the lncRNA secondary structures using a combination of computational prediction methods.

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    Conclusion In summary, enormous progress has been made toward comprehensive annotation on thousands of lncRNAs with respect to their primary sequences, the structural features and their related functions.

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    Genome Res ; 17 On the other hand, computational methods can give large-scale investigation of lncRNA secondary structures with a low cost despite the high false-positive rate. Moreover, it is found that lncRNAs can regulate the expression of protein-coding genes, positively or negatively, and in cis or in trans [ 80 ].

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    Bioinformatics ; 29 8:

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